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RNA-Based Cellular Circuits and Logic Gates: Programming Cells at the Transcriptome Level
Synthetic biology is rapidly moving from simple gene expression to programmable cellular computation. RNA-based cellular circuits leverage the inherent versatility of RNA molecules to construct logic gates, feedback loops, and signal-processing networks within living cells.…
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AAV Vector Encoding FXN for Friedreich’s Ataxia
Assignee: Cornell University & collaborators (licensed to Lexeo Therapeutics, Inc.)Example Patent: US 9,066,966 B2 (Representative patent in the licensed family)Filing / Priority: Before 2012 (priority dates back to foundational frataxin gene therapy work)Issued: 2015–2016 (example patent grant…
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Circular RNA Therapeutics: Engineering Stability and Programmability in RNA Medicine
Circular RNA (circRNA) therapeutics are rapidly emerging as a next-generation platform in RNA medicine. Unlike conventional linear mRNA, circRNAs form covalently closed loops, which confer resistance to exonucleases, enhanced stability, and prolonged protein expression in…
BioTech IP Review 