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Cell subtype‑specific effects of genetic variation in the Alzheimer’s disease brain
What This Covers This research used single‑nucleus RNA sequencing of ~1.5 million individual brain cells from the neocortex of 424 aged donors to map how specific genetic variants influence gene expression (cis‑expression quantitative trait loci, or…
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Small-molecule inhibitor of the JAK family of kinases
Assignee: Janssen Pharmaceutica NV (a Johnson & Johnson subsidiary)Inventors: Edward F. Attiyeh, Kurtis E. Bachman, Gerald C. Chu, Tatiana Koudriakova, David C. Polidori, Gary V. BorzilloFiled: March 9, 2022Patent Granted: August 19, 2025Publication Number: US20220288041…
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Brainwide silencing of prion protein by AAV‑mediated delivery of an engineered compact epigenetic editor
What This Paper Covers This study reports the development and in vivo application of a compact, AAV‑deliverable epigenetic editor designed to silence the prion protein gene (Prnp) across the entire brain — a long‑standing challenge…
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