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Inorganic Salts of Nicotinamide Mononucleotide as Anti‑Aging Agents
What This Patent Covers This patent application claims inorganic salt forms of nicotinamide mononucleotide (NMN) and related compositions and methods for their use in treating or preventing age‑related disorders: 1. Composition Claims 2. Therapeutic Uses…
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CRISPR/dCas9 DNA methylation editing is heritable during human hematopoiesis and shapes immune progeny
What This Study Covers This study demonstrates that targeted DNA methylation editing using a “dead” CRISPR‑Cas9 (dCas9) fused to DNA methyltransferase enzymes can create stable, heritable changes in epigenetic state in human hematopoietic stem and…
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Mitigation of chromosome loss in clinical CRISPR‑Cas9‑engineered T cells
What it Covers This Cell study uncovered a previously under‑recognized safety concern in CRISPR‑Cas9 genome editing as applied to human T cell therapies, a leading class of engineered immunotherapies for cancer and other diseases: Why…
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