RNA-Based Cellular Circuits and Logic Gates: Programming Cells at the Transcriptome Level
Synthetic biology is rapidly moving from simple gene expression to programmable cellular computation. RNA-based cellular circuits leverage the inherent versatility of RNA molecules to construct logic gates, feedback loops, and signal-processing networks within living cells. Unlike traditional DNA-encoded circuits, RNA circuits operate at the transcriptome level, enabling rapid, tunable, and reversible control of cellular behavior.…
Methods of Preparing Dual‑Indexed DNA Libraries for Bisulfite Conversion Sequencing
Assignee: GRAIL, Inc., Menlo Park, CA, USAPatent Number: 12,509,726 B2Filed: February 20, 2025 (Application No. 19/058,911)Issued: December 30, 2025Inventors: Anton Valouev (Palo Alto, CA) & Arash Jamshidi (Redwood City, CA)Patent Classification: Sequencing & Library Preparation (C12Q 1/6874) What This Patent Covers This patent protects novel laboratory methods for constructing dual‑indexed DNA libraries specifically optimized for bisulfite conversion sequencing — a key…
Tray and Dry Reagent Station for Sample Preparation Instrument
Application Number: US 2025030581 A1Filing Date: May 22, 2025Publication Date: Dec 11, 2025Assignee: Beckman Coulter, Inc. (a Danaher company)Jurisdiction: United States (international counterparts may also exist) What This Patent Covers This patent application describes a specialized tray and dry reagent station architecture for use in automated sample preparation instruments—critical components of clinical laboratory analyzers that process patient specimens (e.g., blood, serum,…
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